Words/Phrases that I Loathe (Part I):

Nice (worst offender), esp. as in “That’s nice.”
Issue: Nondescript, not substantive
Implication: You don’t care a whit about what’s being discussed.

Good Luck
Issue: Connotes you in no way think the person is going to make it, achieve desired goal, or get what he or she is going for.
Implication: It also strikes me as being dismissive.

New to the collection, is Kind Offer (does anything say kiss my a** quite like “Thank you for your kind offer!”?)
Issue: When used between friends is too formal
Implication: I don’t want anything from you…ever…